The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2008
Filed:
Oct. 21, 2004
Applicants:
Ronald G. Crystal, New York, NY (US);
Neil R. Hackett, New York, NY (US);
Inventors:
Ronald G. Crystal, New York, NY (US);
Neil R. Hackett, New York, NY (US);
Assignee:
Cornell Research Foundation, Inc., Ithaca, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12P 21/06 (2006.01); C12N 15/00 (2006.01); C12N 5/00 (2006.01); C12N 15/74 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention provides an isolated or purified nucleic acid molecule comprising SEQ ID NO:1, which contains cDNA comprising exons 1-5 of a vascular endothelial growth factor (VEGF) joined to genomic DNA comprising introns 5, 6, and 7 and exons 6, 7, and 8 of VEGF and a mutation in one or more of the splice donor, branch point, and splice acceptor regions, which promotes the production of a VEGFisoform. Expression constructs, compositions, and cells comprising such a nucleic acid molecule also are provided by the invention.