The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2008
Filed:
Mar. 29, 2006
Hassan Mahmound Elokdah, Yardley, PA (US);
Geraldine Ruth Mcfarlane, Monmouth Junction, NJ (US);
David Zenan LI, Princeton, NJ (US);
Lee Dalton Jennings, Chestnut Ridge, NY (US);
David Leroy Crandall, Doylestown, PA (US);
Hassan Mahmound Elokdah, Yardley, PA (US);
Geraldine Ruth McFarlane, Monmouth Junction, NJ (US);
David Zenan Li, Princeton, NJ (US);
Lee Dalton Jennings, Chestnut Ridge, NY (US);
David LeRoy Crandall, Doylestown, PA (US);
Wyeth, Madison, NJ (US);
Abstract
This invention provides compounds of the formula: wherein: X is a chemical bond, —CH— or —C(O)—; Ris alkyl, cycloalkyl, —CH-cycloalkyl, pyridinyl, —CH-pyridinyl, phenyl or benzyl; Ris H, alkyl, cycloalkyl, —CH-cycloalkyl, or perfluoroalkyl; Ris H, halo, alkyl, perfluoroalkyl, alkoxy, cycloalkyl, —CH-cycloalkyl, —NH, or —NO; Ris optionally substituted phenyl, benzyl, benzyloxy, pyridinyl, or —CH-pyridinyl, or the salt or ester forms thereof, as well as methods for using the compounds as inhibitors of plasminogen activator inhibitor-1 (PAI-1) and as therapeutic compositions for treating conditions resulting from fibrinolytic disorders such as deep vein thrombosis and coronary heart disease, and pulmonary fibrosis.