The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2008
Filed:
Aug. 30, 2001
Martin Gleave, Vancouver, CA;
Paul S. Rennie, Richmond, CA;
Hideaki Miyake, Vancouver, CA;
Colleen Nelson, Surrey, CA;
Martin Gleave, Vancouver, CA;
Paul S. Rennie, Richmond, CA;
Hideaki Miyake, Vancouver, CA;
Colleen Nelson, Surrey, CA;
The University of British Columbia, Vancouver, CA;
Abstract
It has been determined that antisense therapy which reduces the expression of TRPM-provides therapeutic benefits in the treatment of cancer, particularly prostate and renal cell cancers. Addition of antisense TRPM-ODN to prostatic tumor cells in vivo is effective for delaying the onset of androgen independence, thus prostate cancer can be treated by initiating androgen-withdrawal to induce apoptotic cell death of prostatic tumor cells in an individual, and administering a composition effective to inhibit expression of TRPM-by the tumor cells. Combined use of antisense TRPM-and taxanes synergistically enhances cytotoxic chemosensitivity of androgen-independent prostate cancer and in human Renal cell cancer. Radiation sensitivity is also enhanced when cells expressing TRPM-are treated with antisense TRPM-ODN. Thus, the antisense TRPM-ODNs can be used to enhance hormone sensitivity, chemosensitivity and radiation sensitivity of a variety of cancer types in which expression of TRPM-has been observed.