The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2008
Filed:
Jun. 21, 2004
Evgeniy Sergeevich Severin, Moscow, RU;
Sergey Evgenyevich Severin, Moscow, RU;
Sergey Viktorovich Lutsenko, Moscow, RU;
Sergey Michaylovich Kiselev, Moscow, RU;
Natalya Borisovna Feldman, Tula, RU;
Evgeniy Sergeevich Severin, Moscow, RU;
Sergey Evgenyevich Severin, Moscow, RU;
Sergey Viktorovich Lutsenko, Moscow, RU;
Sergey Michaylovich Kiselev, Moscow, RU;
Natalya Borisovna Feldman, Tula, RU;
Abstract
The inventive polypeptide is embodied in the form of a similar fragment of the epidermal growth factor of aminoacid ranging from 21 to 31 and capable of efficiently binding with the receptor of the epidermal growth factor as a vector for the directed supply of anticancer agent to tumour cells. The inventive conjugate of said polypeptide contains doxorubicine and has a selective action on cancer tumours and can substantially reduce the resistance of tumour cells with respect to the anticancer agents, the conjugated parts of said agents being binded with the aid of a chemical bond which is unstable in relation to acid hydrolysis. The inventive pharmaceutical composition comprises an efficient quantity of conjugate and a carrier which is fit for intravenous injection. Said invention can be used for medicine for treating cancer patients.