The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2008
Filed:
Aug. 16, 2002
Günter Tovar, Stuttgart, DE;
Thomas Schiestel, Stuttgart, DE;
Herwig Brunner, Stuttgart, DE;
Klaus Pfizenmaier, Tiefenbronn, DE;
Matthias Grell, Darmstadt, DE;
Peter Scheurich, Stuttgart, DE;
Angela Hammer, Stuttgart, DE;
Günter Tovar, Stuttgart, DE;
Thomas Schiestel, Stuttgart, DE;
Herwig Brunner, Stuttgart, DE;
Klaus Pfizenmaier, Tiefenbronn, DE;
Matthias Grell, Darmstadt, DE;
Peter Scheurich, Stuttgart, DE;
Angela Hammer, Stuttgart, DE;
Abstract
The present invention relates to nanoparticles with tumor necrosis factor (TNF) or cytokine immobilized thereon, where TNF or the cytokine is preferably immobilized in the form of a trimer in directed fashion and with retention of its biological activity on the carrier, to methods for the directed immobilization of TNF or cytokine on nanoparticles, to the use of the nanoparticles having immobilized TNF or cytokine for the identification and/or isolation of cytokine- or TNF-binding partners and for the identification and/or isolation of inhibitors of the interaction between TNF or cytokine and its binding partners, to the use of such nanoparticles for preparing a pharmaceutical composition, in particular for the therapy of tumors, and to pharmaceutical and diagnostic compositions which comprise such nanoparticles.