The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2008
Filed:
Dec. 11, 2003
Julian Edward Sale, Cambridge, GB;
Michael Samuel Neuberger, Cambridge, GB;
Sarah Jane Cumbers, Coulsdon, GB;
Shunichi Takeda, Kyoto, JP;
Julian Edward Sale, Cambridge, GB;
Michael Samuel Neuberger, Cambridge, GB;
Sarah Jane Cumbers, Coulsdon, GB;
Shunichi Takeda, Kyoto, JP;
Medical Research Council, London, GB;
Abstract
The invention relates to a method for preparing an antibody-producing cell line capable of directed constitutive hypermutation of a specific nucleic acid region, comprising the steps of: a) screening a clonal cell population for V gene diversity; b) isolating one or more cells which display V gene diversity and comparing the rate of accumulation of mutations in the V genes and other genes of the selected cells; and c) selecting a cell in which the rate of V gene mutation exceeds that of other gene mutation.