The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2008
Filed:
Jun. 18, 2004
Graham P. Allaway, Darnestown, MD (US);
Carl T. Wild, Gaithersburg, MD (US);
Yoshiki Kashiwada, Niigata, JP;
Kuo-hsiung Lee, Chapel Hill, NC (US);
Graham P. Allaway, Darnestown, MD (US);
Carl T. Wild, Gaithersburg, MD (US);
Yoshiki Kashiwada, Niigata, JP;
Kuo-Hsiung Lee, Chapel Hill, NC (US);
Panacos Pharmaceuticals, Inc., Gaithersburg, MD (US);
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Niigata University of Pharmacy and Applied Life Sciences, Niigata, JP;
Abstract
Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have Formula I as described herein, or pharmaceutically acceptable salts thereof; wherein Ris a C-Csubstituted or unsubstituted carboxyacyl or ester thereof; Ris hydrogen, halogen, hydroxyl or —OR, Ris C-Csubstituted or unsubstituted carboxyacyl; and Ris hydrogen or C(CH); wherein the dashed line represents an optional double bond between C20 and C29.