The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2008
Filed:
Apr. 08, 2005
Paul Hinton, Sunnyvale, CA (US);
Naoya Tsurushita, Palo Alto, CA (US);
J. Yun Tso, Menlo Park, CA (US);
Maximiliano Vasquez, Palo Alto, CA (US);
Paul Hinton, Sunnyvale, CA (US);
Naoya Tsurushita, Palo Alto, CA (US);
J. Yun Tso, Menlo Park, CA (US);
Maximiliano Vasquez, Palo Alto, CA (US);
PDL BioPharma, Inc., Redwood City, CA (US);
Abstract
The present invention provides for a modified antibody of class IgG, in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250, 314, and 428 is substituted with another amino acid which is different from that present in the unmodified antibody, thereby altering the binding affinity for FcRn and/or the serum half-life in comparison to the unmodified antibody.