The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2008
Filed:
Jun. 22, 2004
Applicants:
David Shealy, Downingtown, PA (US);
Sam Wu, Broomall, PA (US);
Yan Chen, Wayne, PA (US);
Audrey Baker, Philadelphia, PA (US);
Inventors:
David Shealy, Downingtown, PA (US);
Sam Wu, Broomall, PA (US);
Yan Chen, Wayne, PA (US);
Audrey Baker, Philadelphia, PA (US);
Assignee:
Centocor, Inc., Malvern, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/04 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention concerns antagonists of alphav-containing integrins which have therapeutic activity in oncology applications and methods for selecting such antagonists using a peptide which competes for alphaV-integrin binding with a known monoclonal antibody having demonstrated anti-tumor activity. The claimed peptide represents a conformational epitope or mimotope present on the ligand to which the therapeutic antibodies selectively bind.