The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2008
Filed:
Dec. 09, 2003
Robert A. Kirken, Conroe, TX (US);
Barry D. Kahan, Houston, TX (US);
Stanislaw M. Stepkowski, Pearland, TX (US);
Waldemar Priebe, Houston, TX (US);
Izabela Fokt, Spring, TX (US);
Szymon Kosinski, Menomonee Falls, WI (US);
Robert A. Kirken, Conroe, TX (US);
Barry D. Kahan, Houston, TX (US);
Stanislaw M. Stepkowski, Pearland, TX (US);
Waldemar Priebe, Houston, TX (US);
Izabela Fokt, Spring, TX (US);
Szymon Kosinski, Menomonee Falls, WI (US);
Board of Regents, The University of Texas System, Austin, TX (US);
Abstract
Methods are disclosed for inhibiting or disrupting Janus tyrosine kinase 3 (Jak3) dependent function in cells of lymphoid or myeloid origin, especially for blocking proliferation and function of lymphocytes (e.g., T-cells, B-cells). A Mannich base compound, or a derivative or modified compound, is employed which is capable of selectively inhibiting Jak3 while affecting other protein tyrosine kinase activities to a lesser extent or not at all, to provide beneficial effects such as mitigation of transplant rejection and alleviation of allergic responses with fewer side effects than with conventional immunosuppressive agents.