The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2008
Filed:
May. 14, 2002
Rudolf H. Aebersold, Mercer Island, WA (US);
Huilin Zhou, San Diego, CA (US);
Beate Rist, 31180Giesen, DE;
George J. Vella, Medway, MA (US);
Subhasish Purkayastha, Acton, MA (US);
Sasi Pillai, Littleton, MA (US);
Rudolf H. Aebersold, Mercer Island, WA (US);
Huilin Zhou, San Diego, CA (US);
Beate Rist, 31180Giesen, DE;
George J. Vella, Medway, MA (US);
Subhasish Purkayastha, Acton, MA (US);
Sasi Pillai, Littleton, MA (US);
Other;
Abstract
The invention provides methods for labeling a molecule by contacting a sample molecule with a solid support coupled to a chemical group comprising a cleavable functional group, one or more functional groups, and a reactive group for the sample molecule, under conditions allowing the sample molecule to covalently bind to the reactive group; and cleaving the cleavable functional group, thereby releasing the sample molecule comprising the one or more functional groups, which can be a tag. The invention also provides a solid support covalently coupled to a chemical group comprising a cleavable functional group, a mass spectrometry tag and a reactive group for covalently attaching a sample molecule, wherein the cleavable functional group, the tag and the reactive group are positioned relative to each other to allow transfer of the tag to the sample molecule upon cleavage of the cleavable functional group.