The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2008
Filed:
Aug. 27, 2001
James C. Richards, Ottawa, CA;
Andrew Cox, Gloucester, CA;
Richard Moxon, Oxford, GB;
Derek Hood, Oxford, GB;
Elke K. H. Schweda, Naka, SE;
Martin Månsson, Sodertalje, SE;
James C. Richards, Ottawa, CA;
Andrew Cox, Gloucester, CA;
Richard Moxon, Oxford, GB;
Derek Hood, Oxford, GB;
Elke K. H. Schweda, Naka, SE;
Martin Månsson, Sodertalje, SE;
National Research Council of Canada, Ottawa, CA;
The Chancellor, Masters, and Scholars of the University of Oxford, Oxford, GB;
Other;
Abstract
The present invention relates to a lipopolysaccharide moiety comprising a conserved triheptosyl inner-core moiety of lipopolysaccharide substantially free of variable outer core oligosaccharide chain extension, and to vaccines obtaines therefrom which are cross-reactive forstrains. The invention also relates to defined mutations in the biosynthetic machinery for lipopolysaccharide (LPS;) expression inuseful to obtain the abovementioned moiety. The invention also relates to using conjugates of the LPS from the mutant strains so obtained to elicit a heterologous immune response against a wide range of disease-causingstrains. More specifically, the invention relates to vaccines for prevention of bacterial infections comprising core lipopolysaccharide of