The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2008
Filed:
May. 25, 2005
Joseph M. Patti, Cumming, GA (US);
Jeff T. Hutchins, Cumming, GA (US);
Paul Domanski, Atlanta, GA (US);
Pratiksha Patel, Duluth, GA (US);
Andrea Hall, Acworth, GA (US);
Joseph M. Patti, Cumming, GA (US);
Jeff T. Hutchins, Cumming, GA (US);
Paul Domanski, Atlanta, GA (US);
Pratiksha Patel, Duluth, GA (US);
Andrea Hall, Acworth, GA (US);
Inhibitex, Inc., Alpharetta, GA (US);
Abstract
Monoclonal antibodies which can bind to the ClfA protein and which are generated from binding subdomains or active fragments of the ClfA protein from, including the active fragments proteins from its fibrinogen binding domain such as Clf40 protein, the Clf33 protein, or ClfA N3, are provided which can be useful in the treatment and protection against infection from staphylococcal bacteria such as. In addition, medical instruments can be treated using the monoclonal antibodies of the invention in order to reduce or eliminate the possibility of their becoming infected or further spreading the infection. In particular, the antibodies of the present invention are advantageous because they can prevent adherence of the bacteria to host cells by impairing or inhibiting the ability ofClfA to bind to fibrinogen or fibrin, and thus can be utilized in methods or treating or preventing staphylococcal inventions.