The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 22, 2008
Filed:
Feb. 07, 2005
Applicants:
Ben-zion Dolitzky, Petach Tiqva, IL;
Jean Hildesheim, Mazkeret Batya, IL;
Alisa Berlin, Jerusalem, IL;
Inventors:
Ben-Zion Dolitzky, Petach Tiqva, IL;
Jean Hildesheim, Mazkeret Batya, IL;
Alisa Berlin, Jerusalem, IL;
Assignee:
Teva Pharmaceutical Industries Ltd., Petah Tiqva, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 265/00 (2006.01); C07D 215/38 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention encompasses synthesizing 7-(4-bromobutoxy)-3,4-dihydrocarbostyril by mixing 7-hydroxy-tetrahydroquinolinone, dibromobutane, and at least one base to form a reaction mixture; heating the reaction mixture; cooling the reaction mixture; and isolating the 7-(4-bromobutoxy)-3,4-dihydrocarbostyril from the reaction mixture. The invention also encompasses using phase transfer catalysts during the reaction.