The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 22, 2008
Filed:
Jan. 12, 2006
James Sheppeck, Newtown, PA (US);
T. G. Murali Dhar, Newtown, PA (US);
Lidia Doweyko, Long Valley, NJ (US);
John Gilmore, Yardley, PA (US);
David Weinstein, East Windsor, NJ (US);
Hai-yun Xiao, Belle Mead, NJ (US);
Bingwei V. Yang, Belle Mead, NJ (US);
Arthur M. Doweyko, Long Valley, NJ (US);
James Sheppeck, Newtown, PA (US);
T. G. Murali Dhar, Newtown, PA (US);
Lidia Doweyko, Long Valley, NJ (US);
John Gilmore, Yardley, PA (US);
David Weinstein, East Windsor, NJ (US);
Hai-Yun Xiao, Belle Mead, NJ (US);
Bingwei V. Yang, Belle Mead, NJ (US);
Arthur M. Doweyko, Long Valley, NJ (US);
Bristol-Myers Squibb Co., Princeton, NJ (US);
Abstract
The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory- and immune-associated diseases, and have the structure including all stereoisomers thereof, tautomers thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein X is selected from N, O, and S; Y is N or CR; Z is a ring; and where R, R, R, R, R, R, R, R, R, and Rare as defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising such compounds.