The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 22, 2008
Filed:
Nov. 01, 2004
Graham Cheetham, Abingdon, GB;
Ronald Knegtel, Abingdon, GB;
Lovorka Swenson, Belmont, MA (US);
Joyce T. Coll, Westborough, MA (US);
Suzanne Renwick, Sunbury on Thames, GB;
Peter Weber, Abingdon, GB;
Graham Cheetham, Abingdon, GB;
Ronald Knegtel, Abingdon, GB;
Lovorka Swenson, Belmont, MA (US);
Joyce T. Coll, Westborough, MA (US);
Suzanne Renwick, Sunbury on Thames, GB;
Peter Weber, Abingdon, GB;
Vertex Pharmaceuticals Incorporated, Cambridge, MA (US);
Abstract
The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of Aurora-2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Aurora-2 or homologues thereof.