The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 22, 2008
Filed:
Feb. 11, 2005
Scott Mellis, New Rochelle, NY (US);
Neil Stahl, Carmel, NY (US);
Allen Radin, New York, NY (US);
Steven Weinstein, Hartsdale, NY (US);
Denise Calaprice, Nyack, NY (US);
Margaret Karow, Putnam Valley, NY (US);
Joanne Papadopoulos, LaGrangeville, NY (US);
Scott Mellis, New Rochelle, NY (US);
Neil Stahl, Carmel, NY (US);
Allen Radin, New York, NY (US);
Steven Weinstein, Hartsdale, NY (US);
Denise Calaprice, Nyack, NY (US);
Margaret Karow, Putnam Valley, NY (US);
Joanne Papadopoulos, LaGrangeville, NY (US);
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
Methods of treating, inhibiting, or ameliorating arthritis, including rheumatoid arthritis, osteoarthritis, psoriatic arthritis, ankylosing spondylitis, or juvenile rheumatoid arthritis, in a human subject in need thereof, comprising administering to a subject in need a therapeutic amount of an interleukin 1 (IL-1) antagonist, wherein arthritis inhibited, or ameliorated. The IL-1 antagonist is an IL-1-specific fusion protein comprising an IL-1 binding portion of the extracellular domain of human II-1RAcP, an IL-1 binding portion of the extracellular domain of human IL-1RI, and a multimerizing component antagonist, preferably comprising a sequence selected from the group consisting of SEQ ID NO:4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, or a substantially identical sequence.