The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2008
Filed:
Sep. 04, 2002
Paul Hanselmann, Glis, CH;
Stefan Hildbrand, Riehen, CH;
Paul Hanselmann, Glis, CH;
Stefan Hildbrand, Riehen, CH;
Lonza Ltd., Basel, CH;
Abstract
The invention relates to β-alanine amides of general formula (I), wherein: Rrepresents hydrogen or Calkyl that is optionally substituted by hydroxy, amino, carboxy, carbamoyl, methylmercapto, guanidino, optionally substituted aryl or heteroaryl, and; Rrepresents hydrogen or Rand R, together, form a group of formula —(CH)—, wherein n is 3 or 4. Said β-alanine amides are produced without using an amino protective group by reacting the corresponding amine with a cyanoacetic ester in order to form an acetamide and by effecting a subsequent catalytic hydrogenation. The method is suited, in particular, for producing carcinine (β-alanyl-histamine, R?1=imidazol-4-ylmethyl, R=H), a naturally occurring pseudo dipeptide, which is used as an active ingredient having an antioxidative effect in medicaments and cosmetics.