The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2008
Filed:
Sep. 26, 2003
Andrea Fajdetic, Zagreb, HR;
Gabrijela Kobrehel, Zagreb, HR;
Gorjana Lazarevski, Zagreb, HR;
Stjepan Mutak, Zagreb, HR;
Andrea Fajdetic, Zagreb, HR;
Gabrijela Kobrehel, Zagreb, HR;
Gorjana Lazarevski, Zagreb, HR;
Stjepan Mutak, Zagreb, HR;
GlaxoSmithKline istrazivacki Centar Zagreb d.o., Zagreb, HR;
Abstract
The present invention relates to the new 3-decladinosyl derivatives of 9-de-oxo-9a-aza9a-homoerythromycin A 9a,11-cyclic carbamate of the general formula (I), their pharmaceutically acceptable addition salts with inorganic or organic acids and their hydrates, wherein Rindividually stands for hydrogen, hydroxyl or a group of the formula (II), wherein X individually stands for C-Calkyl group, C-Calkenyl group or X individually stands for C-Calkyl group with at least one incorporated O, S or N atom or X individually stands for (CH)—Ar or X individually stands for (CH)-heterocycloalkyl, wherein (CH)individually stands for alkyl, wherein n is 1-10, with or without incorporated atom O, S or N, wherein Ar individually stands for 5-10-membered monocyclic or bycyclic aromatic ring with 0-3 atom O, S or N, unsubstituted or substituted with 1-3 group, which are selected independently from halogen, OH, OMe, NO, NH, amino-C-Calkyl or amino-C-Cdialkyl, CN, SONH, C-Calkyl, and heterocycloalkyl stands for unaromatic, partially or completely saturated 3-10-membered monocyclic or bicyclic ring system, which includes 3-8-membered monocyclic or bicyclic ring, which includes 6-membered aromatic or heteroaromatic ring connected with a unaromatic ring with or without incorporated O, S or N atom, unsubstituted or substituted with 1-4 group, which are selected independently from halogen, OH, OMe, NO, NH, amino-C-Calkyl or amino-C-Cdialkyl, CN, SONH, CCalkil, —C(O)—, COOH or Rtogether with Rstands for ketone, Rindividually stands for hydrogen or together with Rstands for ketone or together with Rstands for ether, Rindividually stands for hydroxyl, a group of the formula —OX or together with Rstands for ether, Rindividually stands for hydrogen, C-Calkyl group or C-Calkenyl group, and Rindividually stands for hydrogen or hydroxyl protected group, to intermediates for synthesis of other macrolide compounds with antibacterial activity, to the process for their preparation, to their pharmaceutically acceptable addition salts with inorganic or organic acids and their hydrates, to the process for the preparation of pharmaceutical compositions, as well as the use of pharmaceutical compositions for treating bacterial infections