The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2008
Filed:
Oct. 07, 2005
John M. Sanders, Champaign, IL (US);
Yongcheng Song, Urbana, IL (US);
Julian M. W. Chan, Boston, MA (US);
Eric Oldfield, Champaign, IL (US);
Yonghui Zhang, Urbana, IL (US);
John M. Sanders, Champaign, IL (US);
Yongcheng Song, Urbana, IL (US);
Julian M. W. Chan, Boston, MA (US);
Eric Oldfield, Champaign, IL (US);
Yonghui Zhang, Urbana, IL (US);
The Board of Trustees of the University of Illinois, Urbana, IL (US);
Abstract
Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such asfarnesyl diphosphate synthase (FPPS) inhibition,growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy.