The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 15, 2008

Filed:

Dec. 01, 2005
Applicants:

Robert M. Scarborough, Half Moon Bay, CA (US);

Wolin Huang, Foster City, CA (US);

Charles K. Marlowe, Redwood City, CA (US);

Kim A. Kane-mcguire, Belmont, CA (US);

Inventors:

Robert M. Scarborough, Half Moon Bay, CA (US);

Wolin Huang, Foster City, CA (US);

Charles K. Marlowe, Redwood City, CA (US);

Kim A. Kane-McGuire, Belmont, CA (US);

Assignee:

Portola Pharmaceuticals, Inc., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 409/12 (2006.01); A61K 31/517 (2006.01); A61P 7/02 (2006.01);
U.S. Cl.
CPC ...
Abstract

Novel compounds of formulae (I) to (VIII), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I) to (VIII), or a pharmaceutically acceptable salt thereof.


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