The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2008
Filed:
Aug. 28, 2003
Nabil El-tayar, Milton, MA (US);
Michael J. Roberts, Madison, AL (US);
Milton Harris, Hunstville, AL (US);
Wayne Sawlivich, Wilmington, MA (US);
Nabil El-Tayar, Milton, MA (US);
Michael J. Roberts, Madison, AL (US);
Milton Harris, Hunstville, AL (US);
Wayne Sawlivich, Wilmington, MA (US);
Laboratoires Seronosa, Coinsins, Vaud, CH;
Abstract
PEG-IFN-β conjugates, where a PEG moiety is covalently bound to Cysof human IFN-β, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-β.