The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2008
Filed:
Dec. 20, 2004
Jean-françois Bonfanti, Andé, FR;
Koenraad Jozef Lodewijk Andries, Beerse, BE;
Frans Eduard Janssens, Bonheiden, BE;
François Maria Sommen, Wortel, BE;
Jerôme Emile Georges Guillemont, Andé, FR;
Jean Fernand Armand Lacrampe, Le Mesnil-Esnard, FR;
Jean-François Bonfanti, Andé, FR;
Koenraad Jozef Lodewijk Andries, Beerse, BE;
Frans Eduard Janssens, Bonheiden, BE;
François Maria Sommen, Wortel, BE;
Jerôme Emile Georges Guillemont, Andé, FR;
Jean Fernand Armand Lacrampe, Le Mesnil-Esnard, FR;
Tibotec Pharmaceuticals, County Cork, IE;
Abstract
The present invention concerns piperidine-amino-benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula their prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms wherein Q is Calkyl optionally substituted with trifluoromethyl, Ccycloalkyl, Ar, hydroxy, Calkoxy, Calkylthio, Ar-oxy-, Ar-thio-, Ar(CH)oxy, Ar(CH)thio, hydroxycarbonyl, aminocarbonyl, Calkyl-carbonyl, Arcarbonyl, Calkoxycarbonyl, Ar(CH)carbonyl, aminocarbonyloxy, Calkylcarbonyloxy, Arcarbonyloxy, Ar(CH)carbonyloxy, Calkoxy-carbonyl(CH)oxy, mono- or di(Calkyl)aminocarbonyl, mono- or di(Calkyl)-aminocarbonyloxy, aminosulfonyl, mono- or di(Calkyl)aminosulfonyl or a heterocycles selected from the group consisting of pyrrolidinyl, pyrrolyl, dihydropyrrolyl, imidazolyl, triazolyl, piperidinyl, homopiperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, 1-oxo-thiomorpholinyl, 1,1-dioxothiomorpholinyl, pyridyl and tetrahydropyridyl, wherein each of said heterocycle may optionally be substituted with oxo or Calkyl; G is a direct bond or optionally substituted Calkanediyl; Ris Aror a monocyclic or bicyclic heterocycle; one of Rand Ris Calkyl and the other one of Rand Ris hydrogen; in case Ris different from hydrogen then Ris hydrogen or Calkyl, and Ris hydrogen; in case Ris different from hydrogen then Ris hydrogen or Calkyl, and Ris hydrogen; t is 1, 2 or 3; Aris phenyl or substituted phenyl; and Aris phenyl or substituted phenyl. It further concerns their preparation and compositions comprising them, as well as their use as a medicine.