The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2008
Filed:
Mar. 10, 2000
Robert B. Dickson, Silver Spring, MD (US);
Chen-yong Lin, Falls Church, VA (US);
Michael Johnson, Rockville, MD (US);
Shaomeng Wang, Rockville, MD (US);
Istvan Enyedy, Mount Ranier, MD (US);
Robert B. Dickson, Silver Spring, MD (US);
Chen-Yong Lin, Falls Church, VA (US);
Michael Johnson, Rockville, MD (US);
Shaomeng Wang, Rockville, MD (US);
Istvan Enyedy, Mount Ranier, MD (US);
Georgetown University School of Medicine, Washington, DC (US);
Abstract
The invention is directed to a method of detecting a malignancy or a pre-malignant lesion in breast or other tissue, or a pathologic condition, by detecting the presence of single-chain or two-chain forms of matriptase in the tissue. The invention is further directed to a method of treating malignancies, which have the phenotype of matriptase production by administering a tumor formation inhibiting effective amount of concentrate of Bowman-Birk inhibitor (BBIC), or other matriptase inhibitor. The invention also is directed to nucleic acids encoding a matriptase protein or fragments thereof, and their use for structure elucidation and modeling to identify other inhibitors of matriptase, as well as to methods of identifying matriptase modulating agents, including activators and inhibitors.