The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2008
Filed:
Oct. 05, 2005
Bryan Hurst Norman, Indianapolis, IN (US);
Timothy Ivo Richardson, Zionsville, IN (US);
Bryan Hurst Norman, Indianapolis, IN (US);
Timothy Ivo Richardson, Zionsville, IN (US);
Eli Lilly and Company, Indianapolis, IN (US);
Abstract
The present invention relates to novel benzopyran ER-β agonist compounds, pharmaceutical compositions thereof, and use of these compounds to treat a ER-β mediated disease such as nocturia, obstructive uropathy, benign prostatic hypertrophy, obesity, dementia, hypertension, incontinence, colon cancer, prostate cancer, infertility, depression, leukemia, inflammatory bowel disease, and arthritis. Formula (I), wherein G is —O—, —S(O), —CF—, —C(O)—, —CRH— or —CR(OH)—; R is halo, (C-C)alkyl or R—(CH)—; Ris F, hydroxyl, cyano, trifluoromethyl, (C-C)alkyl, (C-C)alkenyl, (C-C)alkynyl, (C-C)alkoxy, (C-C)alkylcarbonyloxy or benzyl; Ris trifluoromethyl or (C-C)alkyl; Ris cyano, hydroxyl, (C-C)alkenyl, (C-C)alkoxy or (C-C)alkoxycarbonyl; n is 0, 1 or 2; and m is 0, 1 or 2; and pharmaceutically acceptable salts thereof.