The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2008
Filed:
Oct. 20, 2004
Tao Wang, Middletown, CT (US);
Zhongxing Zhang, Madison, CT (US);
Nicholas A. Meanwell, East Hampton, CT (US);
John F. Kadow, Wallingford, CT (US);
Zhiwei Yin, Meriden, CT (US);
Qiufen May Xue, Thousand Oaks, CA (US);
Alicia Regueiro-ren, Middletown, CT (US);
John D. Matiskella, Wallingford, CT (US);
Yasutsugu Ueda, Clinton, CT (US);
Tao Wang, Middletown, CT (US);
Zhongxing Zhang, Madison, CT (US);
Nicholas A. Meanwell, East Hampton, CT (US);
John F. Kadow, Wallingford, CT (US);
Zhiwei Yin, Meriden, CT (US);
Qiufen May Xue, Thousand Oaks, CA (US);
Alicia Regueiro-Ren, Middletown, CT (US);
John D. Matiskella, Wallingford, CT (US);
Yasutsugu Ueda, Clinton, CT (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
This invention provides Compounds I having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. Compound I is wherein: A is selected from the group consisting of Calkoxy, aryl and heteroaryl; in which said aryl is phenyl or napthyl; said heteroaryl is selected from the group consisting of pyridinyl, pyrimidinyl, pyrazinyl, triazinyl, furanyl, thienyl, pyrrolyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, quinolinyl, isoquinolinyl, benzofuranyl, benzothienyl, benzoimidazolyl and benzothiazolyl; and said aryl or heteroaryl is optionally substituted with one or two of the same or different members selected from the group consisting of amino, nitro, cyano, hydroxy, Calkoxy, —C(O)NH; and Calkyl, —NHC(O)CH, halogen and trifluoromethyl.