The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2008
Filed:
Oct. 13, 2006
Paola Ciapetti, Altorf, FR;
Laurence Deyon, Illkirch, FR;
Camille-georges Wermuth, Strasbourg, FR;
Jean-françois Pujol, Paris, FR;
Dinah Weissmann, Paris, FR;
Paola Ciapetti, Altorf, FR;
Laurence Deyon, Illkirch, FR;
Camille-Georges Wermuth, Strasbourg, FR;
Jean-François Pujol, Paris, FR;
Dinah Weissmann, Paris, FR;
Biocortech, Paris, FR;
Abstract
The invention relates to novel derivatives of 14,15-dihydro 20,21-dinoreburnamenin-14-ol, having formula (I) in which R represents a radical —AR' wherein A represents a heteroatom and R′ represents a group selected from the group comprising linear or branched C-Calkyl radicals, C-Calkenyls, C-Calkynyls, arylalkyls; esters comprising the formula —R— CO—O—R; amides comprising the formula —R—CO—NZY, wherein Y and Z together can form a cycloalkyl radical or a heterocyclic radical, optionally substituted by one or more alkyl radicals; a radical selected from the group comprising alkyl radicals, alkenyls or alkynyls, substituted by at least one amine with formula —NZY; or one of the pharmaceutically-acceptable salts thereof, including the isomers, enantiomers and diastereoisomers thereof and mixtures thereof. The invention also relates to the use of the novel derivatives for the preparation of a pharmaceutical composition which is intended, in particular, for the treatment and/or prevention of depression, sleep-wake cycle disorders and symptomatic frontal disorders in cognitive components among humans.