The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2008
Filed:
Oct. 14, 2004
Frantisek Zák, Brno, CZ;
Anna Czajka-poulová, Ivancice, CZ;
Frantisek Zák, Brno, CZ;
Anna Czajka-Poulová, Ivancice, CZ;
Pliva-Lachema A.S., Brno, CZ;
Abstract
Oxaliplatin with a low content of accompanying impurities originating from its preparation which contains, by weight, at most 0.01%, preferably less than 0.001%, of alkali metals, at most 0.0005%, preferably less than 0.0002%, of silver, and at most 0.01%, preferably less than 0.001%, of nitrates. A method for preparation of the said oxaliplatin resides in that a suspension of (SP-4-2)-dichloro-[(1R,2R)-1,2-cyclohexanediamine-N,N']platinum(II) in water is treated with silver nitrate, then, after removal of the solid phase, the obtained solution is treated with quaternary ammonium iodide of the formula (R)NI, the separated solid phase is removed and the obtained solution is treated with oxalic acid, and the separated oxaliplatin is isolated, washed with water and a polar organic solvent or their mixture, dried, recrystallised from water, washed with water and polar organic solvent or their mixture, and dried.