The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2008
Filed:
Dec. 24, 2004
Kyu Yang Yi, Taejeon-si, KR;
Sun Kyung Lee, Taejeon-si, KR;
Nak Jeong Kim, Taejeon-si, KR;
Jee Hee Suh, Taejeon-si, KR;
Soon Hee Hwang, Taejeon-si, KR;
Byung Ho Lee, Taejeon-si, KR;
Ho Won Seo, Taejeon-si, KR;
Sun Kyung Hwang, Taejeon-si, KR;
Sung Eun Yoo, Gongju-si, KR;
Kyung Hee Lee, Sungnam-si, KR;
Kyu Yang Yi, Taejeon-si, KR;
Sun Kyung Lee, Taejeon-si, KR;
Nak Jeong Kim, Taejeon-si, KR;
Jee Hee Suh, Taejeon-si, KR;
Soon Hee Hwang, Taejeon-si, KR;
Byung Ho Lee, Taejeon-si, KR;
Ho Won Seo, Taejeon-si, KR;
Sun Kyung Hwang, Taejeon-si, KR;
Sung Eun Yoo, Gongju-si, KR;
Kyung Hee Lee, Sungnam-si, KR;
Korea Research Institute of Chemical Technology, , KR;
Yuyu, Inc., , KR;
Abstract
The present invention relates to furancarbonylguanidine derivatives, a preparation method thereof and a pharmaceutical composition comprising the same. Furancarbonylguanidine derivatives of the present invention inhibit NHE-1 (sodium-hydrogen exchanger isoform 1), which helps recovery of heart function damaged from ischemia/reperfusion and decreases myocardial infarction rate, indicating that they have protective effect on myocardial cells. Thus, furancarbonylguanidine derivatives of the present invention can be effectively used for the prevention and the treatment of ischemic heart diseases such as myocardial infarction, arrhythmia, angina pectoris, etc, and also a promising candidate for a heart protecting agent applied to reperfusion therapy including thrombolytics or cardiac surgery including coronary artery bypass graft, percutaneous transluminal coronary angioplasty, etc.