The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2008
Filed:
Dec. 15, 2004
Takashi Inaba, Osaka, JP;
Julia Haas, Boulder, CO (US);
Makoto Shiozaki, Osaka, JP;
Nicole M. Littmann, Erie, CO (US);
Katsutaka Yasue, Osaka, JP;
Steven W. Andrews, Longmont, CO (US);
Atushi Sakai, Osaka, JP;
Andrew M. Fryer, Erie, CO (US);
Takafumi Matsuo, Osaka, JP;
Ellen R. Laird, Longmont, CO (US);
Akira Suma, Osaka, JP;
Yuichi Shinozaki, Osaka, JP;
Yoshikazu Hori, Osaka, JP;
Hiroto Imai, Osaka, JP;
Tamotsu Negoro, Osaka, JP;
Takashi Inaba, Osaka, JP;
Julia Haas, Boulder, CO (US);
Makoto Shiozaki, Osaka, JP;
Nicole M. Littmann, Erie, CO (US);
Katsutaka Yasue, Osaka, JP;
Steven W. Andrews, Longmont, CO (US);
Atushi Sakai, Osaka, JP;
Andrew M. Fryer, Erie, CO (US);
Takafumi Matsuo, Osaka, JP;
Ellen R. Laird, Longmont, CO (US);
Akira Suma, Osaka, JP;
Yuichi Shinozaki, Osaka, JP;
Yoshikazu Hori, Osaka, JP;
Hiroto Imai, Osaka, JP;
Tamotsu Negoro, Osaka, JP;
Japan Tobacco Inc., Tokyo, JP;
Abstract
The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein Ris —(CH)—X—(CH)-Aetc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and Ais a substituted Chydrocarbon ring group, etc.; Rand Rare the same or different and each is a hydrogen atom, —(CH)—X—(CH)-A, etc., wherein p and q are the same or different and each is 0 to 6, Xis a single bond, etc. and Ais an optionally substituted Chydrocarbon ring group, etc.; Ris —COR, etc., wherein Ris a hydrogen atom, etc.; and Rand Rare the same or different and each is a hydrogen atom, —(CH)—X—(CH)—R, etc., wherein m12 and m12 are the same or different and each is 0 to 6, Xis a single bond, etc. and Ris a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.