The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2008
Filed:
Sep. 29, 2000
Klaus M. Hahn, San Diego, CA (US);
Steven J. Bark, San Diego, CA (US);
Klaus M. Hahn, San Diego, CA (US);
Steven J. Bark, San Diego, CA (US);
The Scripps Research Institute, La Jolla, CA (US);
Abstract
The invention provides intermediates and methods that allow for site-specific modification of peptides after synthesis. Accordingly, functional molecules can be selectively linked to a peptide to provide a peptide conjugate having altered biological, chemical, or physical properties. For example, functional molecules (e.g. biophysical probes, peptides, polynucleotides, and therapeutic agents) can be linked to a peptide to provide a peptide conjugate having differing and useful properties. The invention also provides a compound of formula (III): wherein:Ris a peptide;X is a direct bond or a linking group;Ris hydrogen, (C-C)alkyl, an amino protecting group, or a radical comprising one or more aminooxy groups;Y is a direct bond or a linking group; andD is a functional molecule.