The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2008
Filed:
Jan. 30, 2004
Shubh D. Sharma, Cranbury, NJ (US);
Yi-qun Shi, East Brunswick, NJ (US);
Margarita Bastos, Plainsboro, NJ (US);
Ramesh Rajpurohit, Hillsboro, NJ (US);
Hui-zhi Cai, East Brunswick, NJ (US);
Shubh D. Sharma, Cranbury, NJ (US);
Yi-Qun Shi, East Brunswick, NJ (US);
Margarita Bastos, Plainsboro, NJ (US);
Ramesh Rajpurohit, Hillsboro, NJ (US);
Hui-Zhi Cai, East Brunswick, NJ (US);
Palatin Technologies, Inc., Cranbury, NJ (US);
Abstract
The invention provides methods for identification and determination of target-specific sites in peptides and proteins, including a method for determining the primary sequence of a secondary structure within a known parent polypeptide that binds to the target of interest. In one embodiment of the invention, a residue or mimetic containing a nitrogen atom and a sulfur atom available for binding to a metal ion is serially substituted for single residues in or inserted between adjacent residues in a known primary sequence of a peptide or protein. The resulting sequence is complexed with a metal ion thereby forming a metallopeptide. The resulting metallopeptides are then used in binding or functional assays related to the target of interest, and the metallopeptide(s) which result in significant or substantially decreased or changed binding or functionality are determined to identify the primary sequence involved in such binding or functionality.