The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2008
Filed:
Jun. 01, 2005
Benjamin F. Cravatt, La Jolla, CA (US);
Alan Saghatelian, San Diego, CA (US);
Nadim Jessani, Los Altos, CA (US);
Arul Joseph, Cambridge, MA (US);
Benjamin F. Cravatt, La Jolla, CA (US);
Alan Saghatelian, San Diego, CA (US);
Nadim Jessani, Los Altos, CA (US);
Arul Joseph, Cambridge, MA (US);
The Scripps Research Institute, La Jolla, CA (US);
Abstract
Activity-based compositions for analyzing metalloproteases are disclosed, where the compositions include a chemical compound including a hydroxamate moiety and a benzophenone moiety. Methods for synthesizing these compounds are also disclosed, as well as methods of using them for determining the bioactivity of a compositions comprising active compounds toward a metalloproteases and for determining the potency of an inhibitor against a metalloprotease.