The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2008
Filed:
Apr. 22, 1999
Alexandre Marti, Geneva, CH;
Norbert Lange, Lausanne, CH;
Matthieu Zellweger, Lausanne, CH;
Georges Wagnieres, Morges, CH;
Hubert Van Den Bergh, Goumoens-la-Ville, CH;
Patrice Jichlinski, Le Mont-sur-Lausanne, CH;
Pavel Kucera, Lausanne, CH;
Alexandre Marti, Geneva, CH;
Norbert Lange, Lausanne, CH;
Matthieu Zellweger, Lausanne, CH;
Georges Wagnieres, Morges, CH;
Hubert Van Den Bergh, Goumoens-la-Ville, CH;
Patrice Jichlinski, Le Mont-sur-Lausanne, CH;
Pavel Kucera, Lausanne, CH;
Ecole Polytechnique Federale de Lausanne, Lausanne, CH;
Abstract
The invention concerns a 5-aminolevulinic acid ester (E-ALA) solution for producing a pharmaceutical preparation useful for diagnosing and/or treating tissue and/or cell pathologies by local radiation exposure using radiation emitted by a light source energy followed, in the case diagnosis, by detection of fluorescent protoporphyrin IX (Pp1X). The E-ALA concentration in the solution is less than 1% and ranges between 0.01% and 0.5%. The low E-ALA concentration in the solution increases Pp1X synthesis and homogenises its distribution in the cell layers while highly reducing the secondary toxicity for the treated cells.