Cyclic amine compounds as ccr5 antagonists

Abstract

A compound of formula (I) (wherein Ris a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, Ris a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, or Rand Rmay combine to each other together with A to form a heterocyclic group which may be substituted; A is N or N—R.Y(Ris a hydrocarbon group; Yis a counter anion); Ris a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; n is 0 or 1; Ris a hydrogen atom, a hydrocarbon group which may be substituted, a heterocyclic group which may be substituted, an alkoxy group which may be substituted, an aryloxy group which may be substituted, or an amino group which may be substituted, E is a divalent aliphatic hydrocarbon group which may be substituted by group(s) other than oxo; Gis a bond, CO or SO; Gis CO, SO, NHCO, CONH or OCO; J is methine or a nitrogen atom; and each of Q and R is a bond or a divalent Caliphatic hydrocarbon which may be substituted; provided that J is methine when Gis OCO, that one of Q and R is not a bond when the other is a bond and that each of Q and R is not substituted by oxo group(s) when Gis a bond) or a salt thereof has a potent CCR5 antagonistic activity and can be advantageously used for the treatment or prevention of infectious disease of various HIV in human (e.g. AIDS).