The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2008
Filed:
Apr. 27, 2007
James F. Mcginnis, Edmond, OK (US);
Junping Chen, Oklahoma City, OK (US);
Lily Wong, Oklahoma City, OK (US);
Steve Sezate, Oklahoma City, OK (US);
Sudipta Seal, Oveido, FL (US);
Swanand Patil, Orlando, FL (US);
James F. McGinnis, Edmond, OK (US);
Junping Chen, Oklahoma City, OK (US);
Lily Wong, Oklahoma City, OK (US);
Steve Sezate, Oklahoma City, OK (US);
Sudipta Seal, Oveido, FL (US);
Swanand Patil, Orlando, FL (US);
University of Central Florida Research Foundation, Inc., Orlando, FL (US);
University of Oklahoma, Oklahoma City, OK (US);
Abstract
Methods and compositions useful for neuronal protection in retinal cells in vitro and the protection of mammalian cells from reactive oxygen species in vivo are provided. Ultrafine nano-size cerium oxide particles, less than 10 nanometers in diameter, have been provided to decrease reactive oxygen species (ROS) in retina tissue that generates large amounts of ROS. These reactive oxygen species (ROS) are involved in light-induced retina degeneration and age-related macular degeneration (AMD). Cerium oxide nanoparticles have been used to promote the lifespan of retinal neurons and protect the neurons from apoptosis induced by hydrogen peroxide in vitro and in vivo. The neuronal protection in retinal cells is achieved by decreasing generation of intracellular reactive oxygen species (ROS). Thus, cerium oxide particles are used to promote the longevity of retinal neurons in vitro and mammalian cells in vivo.