The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 2008
Filed:
Mar. 30, 2006
Graziano Castaldi, Briona, IT;
Pietro Allegrini, San Donato Milanese, IT;
Gabriele Razzetti, Sesto S. Giovanni, IT;
Mauro Ercoli, Milan, IT;
Graziano Castaldi, Briona, IT;
Pietro Allegrini, San Donato Milanese, IT;
Gabriele Razzetti, Sesto S. Giovanni, IT;
Mauro Ercoli, Milan, IT;
Dipharma S.p.A., Mereto di Tomba, IT;
Lundbeck Pharmaceuticals, Italy, Padua, IT;
Abstract
A process for the preparation of a compound of formula (I), or a salt thereof wherein R is H, C-Calkyl, aryl or aryl-C-Calkyl; comprising the reaction between a compound of formula (II) wherein Rand Rare independently hydrogen, C-Calkyl, aryl, aryl-C-Calkyl, or Rand R, taken together, form a —(CH)—V—(CH)— group, in which V is NRor C(R)wherein Ris hydrogen, C-Calkyl, aryl or aryl-C-Calkyl; and m and n, which can be the same or different, are 1 or 2; with a compound of formula (III) in which Rand Rare independently C-Calkyl, aryl or aryl-C-Calkyl; in the presence of a Ni (II) salt, an organic ligand and a basic agent, to obtain a compound of formula (I) wherein R is C-Calkyl, aryl or aryl-C-Calkyl and, if desired, its conversion to a compound of formula (I) wherein R is hydrogen or to a salt thereof.