The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 2008
Filed:
Mar. 29, 2004
Sylvia Daunert, Lexington, KY (US);
Sapna Kamlakar Deo, Lexington, KY (US);
Emre Dikici, Lexington, KY (US);
Laura Rowe, Lexington, KY (US);
Sylvia Daunert, Lexington, KY (US);
Sapna Kamlakar Deo, Lexington, KY (US);
Emre Dikici, Lexington, KY (US);
Laura Rowe, Lexington, KY (US);
University of Kentucky Research Foundation, Lexington, KY (US);
Abstract
The invention relates to aequorin and obelin mutants whose emission is shifted with respect to wild type. The shift in emission is accomplished using a combination of mutations of amino acids within aequorin or obelin that affect bioluminescence; use of different types of chromophores, i.e., coelenterazines with variable emission characteristics; and modifications of the photoprotein with fluorophores that will allow for emission of light at longer wavelengths as a result of energy transfer. Additionally, an assay employing aequorin mutants to test for HIV-1 protease inhibitors is disclosed.