The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 2008
Filed:
Mar. 10, 2005
Michael Robin Hale, Bedford, MA (US);
Francois Maltais, Tewksbury, MA (US);
Qing Tang, Acton, MA (US);
Judith Straub, Cambridge, MA (US);
Alexander Aronov, Watertown, MA (US);
Michael Robin Hale, Bedford, MA (US);
Francois Maltais, Tewksbury, MA (US);
Qing Tang, Acton, MA (US);
Judith Straub, Cambridge, MA (US);
Alexander Aronov, Watertown, MA (US);
Vertex Pharmaceuticals Incorporated, Cambridge, MA (US);
Abstract
Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein A, A, TR, X, R, R, R, R, and Rare as described in the specification. The compounds are especially useful as inhibitors of ERK2, Aurora2, GSK3, CDK2, AKT3, and ROCK protein kinases and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, neurodegenerative disorders, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.