The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 2008
Filed:
Jun. 28, 2002
Paul J. Ala, Newark, DE (US);
Janid A. Ali, Waltham, MA (US);
Jacob J. Clement, Vancouver, CA;
Patrick R. Connelly, Harvard, MA (US);
Carlos H. Faerman, Acton, MA (US);
Christopher Faraday, San Francisco, CA (US);
John V. Gazzaniga, Worcester, MA (US);
Andrew S. Magee, Maynard, MA (US);
Salvatore A. Marchese, Malden, MA (US);
Scott T. Moe, Marlborough, MA (US);
Manuel A. Navia, Lexington, MA (US);
Emanuele Perola, Cambridge, MA (US);
Paul Will, Stoneham, MA (US);
Paul J. Ala, Newark, DE (US);
Janid A. Ali, Waltham, MA (US);
Jacob J. Clement, Vancouver, CA;
Patrick R. Connelly, Harvard, MA (US);
Carlos H. Faerman, Acton, MA (US);
Christopher Faraday, San Francisco, CA (US);
John V. Gazzaniga, Worcester, MA (US);
Andrew S. Magee, Maynard, MA (US);
Salvatore A. Marchese, Malden, MA (US);
Scott T. Moe, Marlborough, MA (US);
Manuel A. Navia, Lexington, MA (US);
Emanuele Perola, Cambridge, MA (US);
Paul Will, Stoneham, MA (US);
Pliva D.D., Zagreb, HR;
Abstract
The invention relates to D-Ala-D-Ala ligase inhibitors having the formula: wherein Ris NH; Ris NH; Ris selected from hydrogen, alkyl, amino, hydroxy, alkoxy, and alkylamino; and Rand Rare each independently hydrogen or a substituted or unsubstituted, linear, branched, or cyclic, alkyl, alkenyl, alkynyl, aryl, acyl, aralkyl, or alkaryl group wherein one or more carbon or hydrogen atoms may be substituted by a substituent selected from amino, alkylamino, hydroxyl, alkoxyl, thio, halogen, nitro, and carbonyl; wherein NRRincorporates a substituted or unsubstituted naphthyl group, wherein the substituents are selected from alkoxy, halogen, alkyl, and alkylene, and wherein said naphthyl group in NRRis bonded to N through a substituted or unsubstituted alkylene moiety. These compounds have antibacterial properties based on their ability to bind and inhibit D-Ala-D-Ala ligase, a critical pathway enzyme in bacterial cell-wall synthesis, and are suitable for various antibacterial uses.