The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2008
Filed:
Apr. 05, 2000
Emil F. Pai, Toronto, CA;
Michel H. Klein, Toronto, CA;
Pele Chong, Richmond Hill, CA;
Arthur Pedyczak, Pickering, CA;
Emil F. Pai, Toronto, CA;
Michel H. Klein, Toronto, CA;
Pele Chong, Richmond Hill, CA;
Arthur Pedyczak, Pickering, CA;
University of Toronto, Toronto, Ontario, CA;
Sanofi Pasteur Limited, Toronto, Ontario, CA;
Abstract
The crystal structure of the Fab' fragment of Mab 2F5, a potent neutralizer of both laboratory strains and primary clinical isolates of most clades of HIV-1, both uncompleted and complexed with the largely conserved peptide sequence ELDKWAS of the viral envelope protein gp41, has been elucidated and the characteristics of peptide-protein interactions determined. Having regard to such determination, the peptide-mimetics are constrained in the three-dimensional structure to provide an increased immunogenicity to the epitope sequence.