The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 11, 2008

Filed:

Mar. 10, 2004
Applicants:

Keith John Herzog, Wilmington, DE (US);

Robert Jacobs, Research Triangle Park, NC (US);

Jianxing Kang, Wilmington, DE (US);

Thomas Richard Simpson, Wilmington, DE (US);

James M Woods, Wilmington, DE (US);

Inventors:

Keith John Herzog, Wilmington, DE (US);

Robert Jacobs, Research Triangle Park, NC (US);

Jianxing Kang, Wilmington, DE (US);

Thomas Richard Simpson, Wilmington, DE (US);

James M Woods, Wilmington, DE (US);

Assignee:

AstraZeneca AB, Sodertalje, SE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 243/24 (2006.01); C07D 223/16 (2006.01); C07D 409/12 (2006.01); A61K 31/55 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
Abstract

This invention relates to novel compounds having formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein. The present invention relates to the treatment of neurological disorders related to amyloid β-protein production such as Alzheimer's disease


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