The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2008
Filed:
Jul. 23, 2003
Lloyd Wolfinbarger, Jr., Norfolk, VA (US);
Perry Lange, Virginia Beach, VA (US);
Alyce Linhurst Jones, Virginia Beach, VA (US);
Eric Moore, Carrollton, VA (US);
Barry Nolf, Virginia Beach, VA (US);
Lloyd Wolfinbarger, Jr., Norfolk, VA (US);
Perry Lange, Virginia Beach, VA (US);
Alyce Linhurst Jones, Virginia Beach, VA (US);
Eric Moore, Carrollton, VA (US);
Barry Nolf, Virginia Beach, VA (US);
Lifenet Health, Virginia Beach, VA (US);
Abstract
The invention provides methodologies and apparatus for producing acellular soft-tissue implants, both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. An acellular graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, followed by inducing a pressure mediated flow of a treating solution, then washing the treated tissue to produce the acellular graft. The acellular grafts produced are uniform and non-immunogenic. The inventive method allows for the production of multiple decellularized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes. In clinical use, the decellularized grafts produced exhibit significantly improved in long-term durability and function.