The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 26, 2008
Filed:
Feb. 21, 2006
Gabriele Razzetti, Sesto S. Giovanni, IT;
Simone Mantegazza, Milan, IT;
Roberto Rossi, Pavia, IT;
Pietro Allegrini, San Donato Milanese, IT;
Gabriele Razzetti, Sesto S. Giovanni, IT;
Simone Mantegazza, Milan, IT;
Roberto Rossi, Pavia, IT;
Pietro Allegrini, San Donato Milanese, IT;
Dipharma S.p.A., Mereto di Tomba, IT;
Abstract
A novel process prepares tolterodine, i.e. (R)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine, in the racemic form, as well as intermediates useful for its preparation. Tolterodine free base may be prepared by reacting diisopropyl-(3-phenyl-3-p-tolyloxy-propyl)-amine and 60% aqueous sulfuric acid for three hours under stirring at room temperature. The reaction mixture is then poured over ice/water and then alkalized with 50% NaOH.