The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 26, 2008
Filed:
Mar. 24, 2004
Alfred Samuel Lewin, Gainesville, FL (US);
David Clair Bloom, Gainesville, FL (US);
Gregory Scott Schultz, Gainesville, FL (US);
Sonal Sanjeen Tuli, Gainesville, FL (US);
Jia Liu, Gainesville, FL (US);
Alfred Samuel Lewin, Gainesville, FL (US);
David Clair Bloom, Gainesville, FL (US);
Gregory Scott Schultz, Gainesville, FL (US);
Sonal Sanjeen Tuli, Gainesville, FL (US);
Jia Liu, Gainesville, FL (US);
University of Florida Research Foundation, Inc., Gainsville, FL (US);
Abstract
Hammerhead ribozymes that target components critical to HSV replication (ICP4, UL20, UL30, and UL54) were synthesized and shown to efficiently cleave target RNA encoding a portion of these components in in vitro assays. Several cloned cell lines stably expressing these ribozymes were established. HSV-mediated plaque formation was dramatically reduced in cells stably transfected with an anti-HSV ribozyme compared to non-transfected cells.