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A61K 31/496 (2006.01); A61K 31/44 (2006.01); A61K 31/40 (2006.01); A61K 31/138 (2006.01); A61K 31/085 (2006.01); C07D 403/04 (2006.01); C07D 211/70 (2006.01); C07D 207/12 (2006.01); C07D 217/18 (2006.01); C07D 43/205 (2006.01);

U.S. Cl.

CPC ...

Abstract

This invention provides a compound, or its possible salt, having the formula, wherein: Rand 'Rare OH, optionally independently etherified or esterified; Z is —CHCH— or —C(R,R)—, wherein Rand Rare independently H, (1C-2C)alkyl or form together a spiro(3C-5C)cycloalkyl; Ris H, halogen, CF, or (1C-4C)alkyl; Rand Rare independently H, halogen, —CF, —OCF, (1C-8C)alkyl, hydroxy, (1C-8C)alkyloxy, aryloxy, aryl(1C-8C)alkyl, halo(1C-8C)alkyl, —O(CH)X, wherein X is halogen or phenyl and m=2-4; —O(CH)NRR, —S(CH)NRRor —(CH)NRR, wherein m=2-4 and wherein R, Rare independently (1C-8C)alkyl, (2C-8C)alkenyl, (2C-8C)alkynyl, or aryl, which alkyl, alkenyl and aryl can optionally be substituted with halogen, —CF, —OCF, —CN, —NO, —OH, (1C-8C)alkoxy, aryloxy, carboxyl, (1C-8C)alkylthio, carboxylate, (1C-8C)alkyl, aryl, aryl(1C-8C)alkyl or halo(1C-8C)alkyl; or Rand Rform a 3-8 membered ring structure, optionally substituted with halogen, —CF, —OCF, —CN, —NO, hydroxy, hydroxy(1C-4C)alkyl, (1C-8C)alkoxy, aryloxy, (1C-8C)alkylthio, carboxyl, carboxylate, (1C-8C)alkyl, aryl, aryl(1C-8C)alkyl, halo(1C-8C)alkyl.

Find Patent Forward Citations

Loozen, Hubert Jan Jozef. (2008). [object object] (U.S. Patent No. 7335659). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/7335659

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