The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2008
Filed:
Mar. 11, 2005
Jason B. Crawford, British Columbia, CA;
Gang Chen, British Columbia, CA;
David Gauthier, British Columbia, CA;
Renato Skerlj, Vancouver, CA;
Ian R. Baird, Abbotsford, CA;
Trevor R. Wilson, Langley, CA;
Jason B. Crawford, British Columbia, CA;
Gang Chen, British Columbia, CA;
David Gauthier, British Columbia, CA;
Renato Skerlj, Vancouver, CA;
Ian R. Baird, Abbotsford, CA;
Trevor R. Wilson, Langley, CA;
AnorMED, Inc., Langley, CA;
Abstract
This invention relates to a process for synthesizing heterocyclic pharmaceutical compound which binds to the CXCR4 chemokine receptor. In one embodiment, the process comprises: a) reacting a 5,6,7,8-tetrahydroquinolinylamine and an alkyl aldehyde bearing a phthalimide or a di-tertiary-butoxycarbonyl (di-BOC) protecting group to form an imine; b) reducing the imine to form a secondary amine; c) reacting the secondary amine with a haloalkyl substituted heterocyclic compound, to form a phthalimido-protected or di-tert-butoxycarbonyl protected tertiary amine; and d) hydrolyzing the protected amine to obtain a compound having Formula I'