The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2008
Filed:
Jul. 10, 2002
Stefan Franzen, Apex, NC (US);
Daniel L. Feldheim, Cary, NC (US);
Alexander G. Tkachenko, Raleigh, NC (US);
Marisha L. Godek, Fort Collins, CO (US);
Joseph A. Ryan, Raleigh, NC (US);
Stefan Franzen, Legal Representative, Apex, NC (US);
Stefan Franzen, Apex, NC (US);
Daniel L. Feldheim, Cary, NC (US);
Alexander G. Tkachenko, Raleigh, NC (US);
Marisha L. Godek, Fort Collins, CO (US);
Joseph A. Ryan, Raleigh, NC (US);
Stefan Franzen, legal representative, Apex, NC (US);
North Carolina State University, Raleigh, NC (US);
Abstract
A nanoparticle delivery vehicle, comprising a nanoparticle, an active agent and a nuclear localization signal and methods of modulating gene expression and protein expression employing the nanoparticle delivery vehicle. A representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter of about 30 nm or less, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the nucleus of a target cell. Another representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter greater than or equal to about 30 nm, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the cytoplasm of a cell.