The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2008
Filed:
Feb. 28, 2003
May S. Kung Sutherland, Bothell, WA (US);
James C. Geoghegan, Seattle, WA (US);
John Latham, Seattle, WA (US);
Changpu Yu, Mill Creek, WA (US);
May S. Kung Sutherland, Bothell, WA (US);
James C. Geoghegan, Seattle, WA (US);
John Latham, Seattle, WA (US);
Changpu Yu, Mill Creek, WA (US);
Celltech R&D, Inc., Bothell, WA (US);
Abstract
The SOST gene gives rise to sclerostin, a protein that leads to apoptosis of bone progenitor cells. The invention provides antagonists to the sclerostin protein, and methods for identifying new sclerostin antagonists. The invention also provides molecules that can depress expression of the SOST gene, as well as methods for identifying such molecules. Such molecules and antagonists are useful for increasing bone mineralization in mammals, for example, in the treatment of osteoporosis.