The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2008
Filed:
Jun. 21, 2000
Milind Rajopadhye, Westford, MA (US);
John A. Barrett, Groton, MA (US);
Alan P. Carpenter, Jr., Carlisle, MA (US);
Edward H. Cheesman, Lunenberg, MA (US);
Thomas D. Harris, Salem, NH (US);
Milind Rajopadhye, Westford, MA (US);
John A. Barrett, Groton, MA (US);
Alan P. Carpenter, Jr., Carlisle, MA (US);
Edward H. Cheesman, Lunenberg, MA (US);
Thomas D. Harris, Salem, NH (US);
Bristol-Myers Squibb Pharma Company, Princeton, NJ (US);
Abstract
The present invention describes novel compounds of the formula:(Q)—L—C,useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The present invention also provides novel compounds useful for imaging atherosclerosis, restenosis, cardiac ischemia, and myocardial reperfusion injury. The present invention also provides novel compounds useful for the treatment of rheumatoid arthritis. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety. The imageable moiety is a gamma ray or positron emitting radioisotope, a magnetic resonance imaging contrast agent, an X-ray contrast agent, or an ultrasound contrast agent.